Synthesis, Characterisation, Biological and Molecular Docking Studies of Aconitic Acid Based Co-Polyester Kumar Vanitha Krishna*, Mrs Raveendiran Nanthini Postgraduate and Research, Department of Chemistry, Pachaiyappa's College, University of Madras, Chennai, India *Corresponding Author E-mail: vanabhava@yahoo.co.in
Online published on 24 October, 2018. Abstract Aliphatic polyester elastomers are class of biomaterials that are widely used for drug delivery and tissue engineering. The demand for biodegradable non toxic elastomers is ever increasing due to their dexterity of being biocompatible and biodegradable. A series of novel biodegradable polyesters are synthesised, using multifunctional non-toxic monomers: aconitic acid, citric acid, sebacic acid and glycerol by melt condensation method, followed by post polymerisation. The chemical structure of the elastomer are characterised by FT-IR, 1H NMR and 13C NMR. TGA, and DSC techniques are used to determine the physical properties of the polymers. The low Tg values and a higher Tm and Td illustrates the elasticity and stability of the synthesised elastomers respectively which makes it suitableas implant materials. The CAM assay exhibits the wound healing property which is further confirmed by the molecular docking with the matrix metalloproteinase. Chorioallantoic membrane (CAM) assay shows that the formation of blood vessels is 178% and 169% greater than the standard. Lib dock score of these polymers with MMP2, MMP8and MMP12 suggests that are effective MMP inhibitors. The observed results unambiguously suggest that the synthesized elastomer poly(glycerol acotinate-co-glycerol citrate)PACGL and poly(glycerol acotinate-co-glycerol sebacate)PASGL have excellent wound healing ability and are suitable as potent biomaterials in the biomedical field. Top Keywords Elastomer, Aconitic acid, Molecular docking, CAM assay, Implant biomaterial. Top |