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Asian Journal of Research in Chemistry
Year : 2018, Volume : 11, Issue : 4
First page : ( 705) Last page : ( 709)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2018.00124.4

Chemometric-Assisted UV Spectrophotometric Method for Determination of Cefixime Trihydrate and Cloxacillin Sodium in Pharmaceutical Dosage Form

Gandhi Santosh V.1,*, Sonawane Pratidnya S.2

1Professor, AISSMS College Pharmacy, Savitribai Phule Pune University, Pune, India-411001

2AISSMS College of Pharmacy, Near RTO, Kennedy Road, Pune-411001

*Corresponding Author E-mail: santoshvgandhi@rediffmail.com

Online published on 24 October, 2018.


UV spectrophotometry is the simple, precise and accurate method of analysis. Chemometrics are set of statistically improved and verified multicomponent methods for analysis. These methods of analysis were developed using Principle Component Regression (PCR) and Partial Least Square (PLS) to apply and study new technique in project work. The spectra of both drugs were recorded at concentrations within their linear ranges at 2.0–12.0 μg/ml for Cefixime and 5.0–30.0 μg/ml for Cloxacillin. The spectra were recorded in the 220 nm-260 nm wavelength range at wavelength interval of 0.5 nm. International Conference on Harmonization Q2 (R1) (ICH) guidelines were followed to validate the method. The proposed method can be used as alternative analytical tool in quality control of these drugs.



Chemometrics UV-assisted Studies, Cefixime trihydrate, Cloxacillin Sodium, PCR, PLS.


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