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Asian Journal of Research in Chemistry
Year : 2018, Volume : 11, Issue : 3
First page : ( 671) Last page : ( 680)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2018.00120.7

Absolute configuration of boceprevir chiral fragment-B by chiral chromatographic, spectroscopic, thermal and crystallization techniques.

Rajana Nagaraju1,3,*, Pallavi V.1, Madhavan P.1, Mohan H. Rama1, Babu J. Moses2, Basavaiah K.3

1Technology Development Center, Custom Pharmaceutical Services, Dr. Reddy's Laboratories Ltd, Miyapur, Hyderabad, 500049, India

2Integrated Product Development Organization, Dr. Reddy's Laboratories, Innovation Plaza, Bachupally, Telangana, 500072, India

3Department of Inorganic & Analytical Chemistry, Andhra University, Visakhapatnam (AP), 530003, India

*Corresponding Author E-mail: nagarajurajana@drreddys.com, nagarajrajana@gmail.com

Online published on 21 August, 2018.


During reverse phase chromatography, the chiral fragment-B of Boceprevir i.e methyl (1R, 2S, 5S)-6, 6-dimethyl3-azabicyclo[3.1.0]hexane-2-carboxylate hydrochloride was separated along its cis isomer, acid impurity and ester impurity. The R and S isomers of Trans isomers were separated by chiral chromatography; the chiral S isomer was characterized by the 1D NMR, FT-IR, Mass, SOR, X ray studies and differential scanning colorimetry.

A chiral fragment-B of Boceprevir



Boceprevir, Absolute configuration, 1D NMR, Chiral chromatography.


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