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Asian Journal of Research in Chemistry
Year : 2018, Volume : 11, Issue : 2
First page : ( 427) Last page : ( 431)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2018.00078.0

New High Performance Liquid Chromatographic Method for Determination of Vilazodone HCl in Pharmaceutical Dosage Form

Yadav Nita1,*, Anju G2

1Department of Pharmacy, SRMSCET, Bareilly, Uttar Pradesh, India

2B. N. Institute of Pharmaceutical Sciences, Udaipur, RAJ, India

*Corresponding Author E-mail: raj_neetu78@rediffmail.com

Online published on 2 June, 2018.

Abstract

A simple, precise, rapid and accurate reverse phase HPLC method developed for the estimation of Vilazodone in Tablet dosage form by using a C8 Chromasil column (250 × 4.6 mm, 5μm particle size), with mobile phase containing mixture of phosphate buffer and methanol in ratio of 30: 70, v/v with pH adusted to 5 with orthophosphoric acid was used. The flow rate was 1 ml/min and the effluents were monitored at 232 nm. The retention time was 6.008 min. The detector response was linear in the concentration of 4–20 mcg/ml. The respective linear regression equation being y = 66733x-4974. The limit of detection and limit of quantification was 0.418and 1.267mcg/ml respectively. The percentage assay of Vilazodone was 100.15%. The method was validated by determining its system suitability, precision, accuracy, and robustness parameters.. The results of the study showed that the proposed RP-HPLC method is simple, rapid, precise and accurate; this is useful for the routine determination of Vilazodone in bulk drug and in its pharmaceutical dosage form.

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Keywords

Vilazodone, Calibration curve, RP-HPLC, Estimation, and Tablets.

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