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Asian Journal of Research in Chemistry
Year : 2018, Volume : 11, Issue : 2
First page : ( 312) Last page : ( 318)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2018.00058.5

Studies on Synthesis of Aromatic Schiff Bases. Part-VI. Synthesis, Characterization and Biological Activity of Ketimines from 5-Chloro-2-hydroxy-4-methyl-acetophenone with substituted anilines

Salve S. B.*, Patil C. J.**, Mahajan H. A.

Smt. G. G. Khadse College, Muktainagar, Dist-Jalgaon-425 306, Maharashtra, India

*Corresponding Author E-mail: sanjivsalve@gmail.com


Online published on 2 June, 2018.


The condensed reaction of aromatic ketone, 5-Chloro-2-hydroxy-4-methyl-acetophenone with aniline and its derivatives each separately viz. Aniline, 4-Amino-phenol, 2-Amino-thiophenol, 4-Amino-thiophenol, 4-Chloro-2-nitro-aniline, 2-Amino-benzonitrile and 4-Amino-benzonitrile and reacted efficiently to produced a series of ketimines in high yield and purity. These were analyzed by employing the TLC technique. All the products were characterized by their colour, physical constant, TLC, elemental analysis and spectral(UV-Vis and FTIR) method. After confirming their desired molecular studies, these ketimines were studied for their antifungal activity using A. alternata, and F. oxysporum.



Schiff bases, ketimines, 5-Chloro-2-hydroxy-4-methyl-acetophenone, dialkylaniline, TLC, UV-Vis and antifungal activity.


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