Eco friendly synthesis of N’-Arylidene-2-((7-bromo-2-methylpyrido[2, 3-B]pyrazin-3-yl)oxy)acetohydrazides Rajeshwari M* Telangana University Dichpally, Nizamabad, Telangana, 503322 *Corresponding Author E-mail: rajithamadipelly@yahoo.com
Online published on 2 June, 2018. Abstract 5-bromo 2, 3-diamino pyridine and ethylpyruvate react each other to form 7-bromo-2-methylpyrido[2, 3b]pyrazin-3-ol (1) which further reacts with ethylchloroacetate and formethyl 2-((7-bromo-2-methylpyrido[2, 3b]pyrazin-3-yl)oxy)acetate (2). Compound 2 on reaction with hydrazinehydrate gives 2-((7-bromo-2methylpyrido[2, 3-b]pyrazin-3-yl)oxy)acetohydrazide (3), which on condensation with different aldehydes produce N’-Arylidene-2-((7-bromo-2-methylpyrido[2, 3-b]pyrazin-3-yl)oxy)acetohydrazides (4a-e). Top Keywords Heterocycles, Aldehydes, Antitumor Agents, Hydrogen Bond, Corrosion, Hormones. Top |