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Asian Journal of Research in Chemistry
Year : 2018, Volume : 11, Issue : 2
First page : ( 269) Last page : ( 274)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2018.00050.0

Catalyst free Synthesis of Phenyl Hydrazones and their Biological Evaluation

Suryawanshi Vikas B.1, Momin Kalimoddin I.2, Bondge Abhay S.3, Dawale Jairaj K.4,*

1Department of Chemistry, KMC College, Khopoli, Maharashtra--410203, India

2Rajarshi Shahu College, Latur, Maharashtra-413512, India

3Shivneri College, Shirur Anantpal, Dist. Latur, Maharashtra-413544, India

4Research Laboratory for Pure and Applied Chemistry, M. M. College, Nilanga, Dist. Latur, MH-413521, India

*Corresponding Author E-mail: jairajdawale@gmail.com

Online published on 2 June, 2018.

Abstract

An efficient route for the synthesis of aromatic hydrazones has been developed using simple protocol in water. The synthesis was completed by using commercially available starting material. Synthesized intermediates showed potent inhibition of Mycobacterium tuberculosis. The protocol shows broad substrate scope. The phenyl hydrazine shown drug like properties and is a good starting point for further exploration in antituberculosis drug discovery.

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Keywords

Benzophenone, hydrazine hydrate, green, drug, ethanol.

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