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Asian Journal of Research in Chemistry
Year : 2018, Volume : 11, Issue : 2
First page : ( 241) Last page : ( 243)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2018.00045.7

Synthesis, Characterization of Benzimidazole Derivatives carrying Pyridine Moiety

Prasad K. Durga1, Rani M. Sandhya2,*, Anusha D.2

1Natco Research Centre, Sanath Nagar, Hyderabad-500018

2Department of Pharmaceutical Chemistry, Pulla Reddy Institute of Pharmacy, Gummadidala, Sangareddy, Telangana-502110

*Corresponding Author E-mail: sandhya.madala@gmail.com

Online published on 2 June, 2018.

Abstract

A new series of 1-methyl-2{[(3, 4, 5-tri substituted pyridine2-yl) methyl] sulfanyl}-5-nitro-1H-benzimidazoles 3a-3b were synthesized by coupling 1-methyl-2-mercapto-5-nitro-1H-benzimidazole 1 with various pyridine derivatives 2a-2b in the presence of a base at room temperature, Upon further oxidation of these Benzimidazole derivatives 3a-3b in presence of MCPBA gives 1-methyl-2{[(3, 4, 5-tri substituted pyridine2-yl) methyl] sulfinyl}-5-nitro-1H-benzimidazoles 4a-4b. The group frequencies of IR and NMR spectra were assigned.

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Keywords

1-methyl-2-mercapto-5-nitro-1H-benzimidazole, pyridine derivatives, MCPBA, coupling, IPE.

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