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Asian Journal of Research in Chemistry
Year : 2018, Volume : 11, Issue : 2
First page : ( 236) Last page : ( 240)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2018.00044.5

Synthesis of Some New N-Mannich Bases Derivatives of Phenytoin

Mathapati Sushil R.1, Suryawanshi Vikas B.2, Bondge Abhay S.3, Dawale Jairaj K.4,*

1Department of Chemistry, S. M. P. Mahavidyalaya, Murum-413605, Dist.-Osmanabad, India

2Department of Chemistry, KMC College, Khopoli, Maharashtra-410203, India

3Shivneri College, Shirur Anantpal, Dist. Latur, Maharashtra-413544, India

4Research Laboratory for Pure and Applied Chemistry, M. M. College, Nilanga, Dist. Latur, MH-413521, India

*Corresponding Author E-mail: amritkund_jk@rediffmail.com

Online published on 2 June, 2018.


5, 5-Diphenylhydantoin (Phenytoin) is a well-known anticonvulsant and antiarrhythmic drug which may cause unwanted side effects. In order to avoid the adverse effects of phenytoin, especially on the central nervous and cardiovascular systems, a small series of amine derivatives (Mannich bases) were designed containing phenytoin nucleus. For this synthesis we follow green methodology during synthesis of phenytoin from benzyl and urea.



Phenytoin, Mannich bases, Green methods, Benzyl.


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