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Asian Journal of Research in Chemistry
Year : 2018, Volume : 11, Issue : 1
First page : ( 111) Last page : ( 120)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2018.00024.X

Synthesis of Tetrahydroquinoline derivatives via One Pot Multi-component (4+2) Cycloaddition (Povarov) Reaction

Chavan Pravin1,*, Jadhav Shivaji2, Rai Megha2

1Department of Chemistry, Doshi Vakil Arts and G.C.U.B. Science and Commerce College, Goregaon-Raigad, Maharashtra-India

2Department of Chemistry, Dr. Rafiq Zakaria College for Women, Navkhanda, Jublee Park, Aurangabad, Maharashtra-India

*Corresponding Author E-mail: chemistryp141286@gmail.com

Online published on 26 March, 2018.


In the presence of InCl3 as a catalyst one-pot (4π+2π) cycloaddition reaction of aromatic aldehydes, arylamines and DHF in ethanol proceeded smoothly to give tetrahydroquinoline derivatives (4a-4j) in excellent yields. Advantages of this method are shorter reaction time and biologically important.



Tetrahydroquinoline Derivatives, Aromatic Aldehyde, Povarov reaction and Reflux.


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