Synthetic and Natural Compounds as Anti-Cancer Agents-A Review
Cancer, the irregular and uncontrolled cell division and abnormal growth of tissues is the cause of increasing number of deaths all over the world. The cause of death may be environmental factors, genetic mutations or prolonged infections or other abnormalities. The timely diagnosis and the treatment thereof is a major concern for the control. The various remedies and treatment factors have been in consideration since long. The various synthetic drugs like Abiraterone Acetate, Abitrexate (Methotrexate), Adcetris (Brentuximab Vedotin), Bavencio (Avelumab), BEACOPP, Becenum (Carmustine), Capecitabine, Cabazitaxel, Chlorambucil are in clinical use with good result in Phase-1 but still not effectively potent. The natural products obtained from medicinal plants, marine plants, blue-green algeae include vinblastine, vincristine, camptothecin derivatives, taxol, phyllotoxin derivatives, flabones, etoposides are found to have selective activity against cancer and related targets despite their toxicity and relative ineffectiveness in higher stages of carcinoma.
Cancer cells, natural products, carcinoma, malignant, Plants.