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Asian Journal of Research in Chemistry
Year : 2017, Volume : 10, Issue : 4
First page : ( 573) Last page : ( 576)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2017.00095.5

Synthesis and antioxidant activity of some new substituted pyrazolo [4, 5-e]4H-pyrimido[2, 3-b] benzimidazoles

Ubale Prashant N., Vartale Sambhaji P.*, Sontakke Sandip G.

PG Research Centre, Department of Chemistry, Yeshwant Mahavidyalaya, Nanded-431602 (MS), INDIA

*Corresponding Author E-mail: spvartale@gmail.com

Online published on 17 October, 2017.

Abstract

2-Amino benzimidazole condensed with ethyl-2-cyano-3, 3-bis(methylthio)acrylate using catalytic amount of potassium carbonate and DMF as solvent to form 3-cyano-2-metylthio-4-oxo-4H-pyrimido [1, 2-a] benzimidazole (3). The formed compound (3) reacted with differently substituted aryl/heteryl hydrazino compounds then it gives series of substituted pyrazolo [4, 5-e]-4H-pyrimido [2, 3-b] [1, 3] benzimidazoles (5a-h). Structure of compounds were confirmed by spectroscopic techniques IR, mass, 1H & 13C NMR and analytical properties. all synthesized compounds were screened for their antioxidant activity.

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Keywords

Pyrazole, pyrimido benzimidazole, fused heterocycles, antioxidant activity.

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