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ASIAN JOURNAL OF RESEARCH IN CHEMISTRY
Year : 2017, Volume : 10, Issue : 3
First page : ( 312) Last page : ( 318)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2017.00052.9

Synthesis, characterisation, DNA binding/cleavage, anticancer and antimicrobial activity of ternary copper(II) complexes

Dhakshanamoorthy S.1, Krishnan M. Murali2, Arumugham M.N.1,*

1Department of Chemistry, Thiruvalluvar University, Vellore-632 115, Tamilnadu, India.

2Department of Chemistry, Bannari Amman Institute of Technology, Sathyamangalam-638 401, Tamilnadu, India

*Corresponding Author E-mail: aru_mugham@yahoo.com

Online published on 22 September, 2017.

Abstract

Ternary copper(II) complexes [Cu(L-Ser)(HB)(U)](ClO4) (1 and 2) where L-Ser = L-Serine, U = Urea, HB is a N,N-donor heterocyclic bases, viz. 1,10-phenanthroline (phen) (1), 2, 2’- bipyridine (bpy) (2), are synthesized, characterized, and their DNA binding, cleavage and antimicrobial activities are studied. The one-electron paramagnetic complexes display a d-d band near 600 nm in water. Binding interactions of the complexes with calf thymus (CT) DNA have been investigated by absorption, emission, viscosity, and cyclic voltammetry studies. The complexes cleave the supercoiled DNA (pBR 322) to its nicked circular form in the presence of gallic acid at appropriate complexes concentration. The phen complex (1) displays significant binding propensity to the CT DNA. The bpy complex (2) does not show any significant binding to the DNA and hence poor cleavage efficiency.

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Keywords

1, 10-phenanthroline, 2, 2’-bipyridine, copper, DNA binding, MTT assay.

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