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Year : 2017, Volume : 10, Issue : 3
First page : ( 280) Last page : ( 290)
Print ISSN : 0974-4169. Online ISSN : 0974-4150.
Article DOI : 10.5958/0974-4150.2017.00046.3

Synthesis and biological activities of novel thieno[3, 2-d] pyrimidine derivatives

Prabhakar Virupakshi1,*, Babu K. Sudhakar2, Ravindranath L. K.2, Venkateswarlu B.3

1SVR Engineering College, Jawaharlal Nehru Technological University-Ananthapuramu (Jntu-A), Nandyal, Kurnool (Dist), A.P., India.

2Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu, (AP) India.

3PBR VITS, Jawaharlal Nehru Technological University (Jntu-A), Kavali, Nellore (Dist), (A.P.) India.

*Corresponding Author E-mail: virupakshi.prabhakar@gmail.com

Online published on 22 September, 2017.


A series of novel 4-Substituted/Heterocyclic-N-(4-thiomorpholinothieno[3,2-d]pyrimidin-2-yl)benzamide (8a-j) derivatives were synthesized by a Five-step procedure that afforded advantages of mild reaction conditions, simple protocol and good yields. The structures of the final compounds were confirmed by IR, NMR, EI-MS. The final compounds were screened for their anti-bacterial activity against Staphylococcus aureus (S. aureus) and Bacillus subtilis (B. subtilis)from Gram positive group of bacteria and Pseudomonas aeruginosa (P. aeruginosa) and Escherichia coli (E. coli)from Gram negative group of bacteria and antifungal activity against Aspergillus niger (A. niger) and Candida albicans (C. albicans). Anti-bacterial and anti-fungal activities were Evaluated and compared with the standard drugs Such as Amoxicillin & Flucanazole From anti-bacterial and antifungal activity screening results, it has been observed that compounds 8j, 8i, 8e and 8f possess good activity.



Thieno [3,2-d] Pyrimidine, 2-chloro-4-thio morpholine Thieno[3, 2-d]pyrimidine synthesis, Anti-bacterial, Anti-fungal activity, HATU.


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