Microwave assisted synthesis and antifungal studies of 5-amino thiadiazole substituted pyrimidine compounds Karthic R1,3,*, Andrews B2,4, Subramani K1,3 1PG & Research Department of Chemistry, Islamiah College, Vaniyambadi-635751, India 3Affiliated to Thiruvalluvar University, Vellore, Tamil Nadu, India 2Department of Chemistry, Priyadarshini Engineering College, Vaniyambadi, India 4Affiliated to Anna University, Chennai, Tamil Nadu, India *Corresponding Author E-mail: karthicrm@gmail.com
Online published on 17 July, 2017. Abstract Simple synthetic methods of 5-(5-amino-1, 3, 4-thiadiazol-2yl)-3, 4-dihydro-6-methyl-4-phenylpyrimidin-2(1H)-thione (3f-j) are described. Compound 1 is converted to carbothiamide 2 by reacting compound 1 with thiosemicarbazide in catalytic amount of acetone is irradiated with help of domestic microwave oven (200W) for 2 minutes. Compound 2 is act as a key intermediate for the final compounds. The compound 2 is converted to corresponding thiadiazole 3 by treatment with conc. H2SO4 and NH3. Structural elucidation is accomplished by IR, 1H and 13CNMR, Elemental analysis and GC-Mass spectral data of the synthesized compounds. Few of these Pyrimidine derivatives have been evaluated for their possible antifungal activity. Most of the tested compounds show significant antifungal activity. Top Keywords Pyrimidine, thiadiazole, carbothiamide, thiosemicarbazide, antifungal activity. Top |