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Asian Journal of Pharmacy and Technology
Year : 2019, Volume : 9, Issue : 4
First page : ( 253) Last page : ( 259)
Print ISSN : 2231-5705. Online ISSN : 2231-5713.
Article DOI : 10.5958/2231-5713.2019.00042.4

Colorimetric Estimation of Nebivolol Hydrochloride in Bulk and Pharmaceutical Dosage Form

Ahamed Syed Sagheer*, Khaleel Mohamed, Havannavar Nirmal. T., Miyan Syed Shariff

Department of Pharmaceutical Analysis and Quality Assurance, M.M.U College of Pharmacy, Ramanagara

*Corresponding Author E-mail: hapsagheer@gmail.com, Helloprofessor4610@gmail.com

Online published on 31 December, 2019.

Abstract

A simple, sensitive and accurate colorimetric estimation method was developed for the assay of Nebivolol hydrochloride in pure drug and tablet dosage form. The yellowish-orange coloured chromogen so produced was measured at 392nm for Nebivolol hydrochloride. It obeyed beer's law at the concentrations of 4–36μg/ml with coefficient of correlation (r2) of 0.999. Limit of detection (LOD) was found to be 2.558μg/ml and Limit of quantitation (LOQ) was found to be 3.764μg/ml. Validation of the method yielded good results concerning range, linearity, precision, accuracy, robustness and ruggedness. The excipients found in the formulation did not hamper the method.

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Keywords

Nebivolol hydrochloride, antihypertensive, colorimetry, method validation.

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