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Asian Journal of Pharmacy and Technology
Year : 2019, Volume : 9, Issue : 4
First page : ( 253) Last page : ( 259)
Print ISSN : 2231-5705. Online ISSN : 2231-5713.
Article DOI : 10.5958/2231-5713.2019.00042.4

Colorimetric Estimation of Nebivolol Hydrochloride in Bulk and Pharmaceutical Dosage Form

Ahamed Syed Sagheer*, Khaleel Mohamed, Havannavar Nirmal. T., Miyan Syed Shariff

Department of Pharmaceutical Analysis and Quality Assurance, M.M.U College of Pharmacy, Ramanagara

*Corresponding Author E-mail: hapsagheer@gmail.com, Helloprofessor4610@gmail.com

Online published on 31 December, 2019.


A simple, sensitive and accurate colorimetric estimation method was developed for the assay of Nebivolol hydrochloride in pure drug and tablet dosage form. The yellowish-orange coloured chromogen so produced was measured at 392nm for Nebivolol hydrochloride. It obeyed beer's law at the concentrations of 4–36μg/ml with coefficient of correlation (r2) of 0.999. Limit of detection (LOD) was found to be 2.558μg/ml and Limit of quantitation (LOQ) was found to be 3.764μg/ml. Validation of the method yielded good results concerning range, linearity, precision, accuracy, robustness and ruggedness. The excipients found in the formulation did not hamper the method.



Nebivolol hydrochloride, antihypertensive, colorimetry, method validation.


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