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Asian Journal of Pharmacy and Technology
Year : 2019, Volume : 9, Issue : 1
First page : ( 31) Last page : ( 39)
Print ISSN : 2231-5705. Online ISSN : 2231-5713.
Article DOI : 10.5958/2231-5713.2019.00007.2

Appliance of Augmented Simplex Mixture Design in Extraction of Lemon Seed Mucilage for Stabilization of Nanosilver

Karande Kailas Madhukar1,*, Gawade Shivaji Prataprao2

1Satara College of Pharmacy, Satara, Maharashtra

2Veer Vijay Pharmacy College, Fatehpur Bhado, Chhutmalpur Dist.-Saharanpur (UP)

*Corresponding Author E-mail: karandekailas@gmail.com

Online published on 16 March, 2019.


Present work hypothesized on the stabilization of NS by viscous medium formed by mucilage of lemon seed. Nanoparticles have a particular propensity to lower their very high surface energy, which is the origin of their thermodynamic instability. Uncovered nanoparticles tend to stabilize themselves either by sorption of ions/molecules from the environment or by lowering the surface area through agglomeration. With this background we have hypothesized ability of lemon seed mucilage to stabilize silver nanoparticles (NS). Augmented simplex mixture design was used to finalize the levels of independent variables. Temperature, time of extraction and water seed ratio was finalized as independent variables. Yield of extraction was the dependent variable. Predicted design was validated conducting experimental run. Extracted lemon seed mucilage was used to synthesize NS. High yield NS was successfully synthesized. Confirmation of synthesis was performed by visual observations, UV-Visible spectroscopic analysis, Transmission electron microscopy and zeta potential determination. Characterization revealed that NS were synthesized having range 20-50nm with positive zeta value of 30.01.



Augmented simplex mixture design, silver nanoparticles, lemon seed mucilage.


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