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Asian Journal of Pharmacy and Technology
Year : 2019, Volume : 9, Issue : 1
First page : ( 15) Last page : ( 22)
Print ISSN : 2231-5705. Online ISSN : 2231-5713.
Article DOI : 10.5958/2231-5713.2019.00004.7

A Principal Component Analysis-Based method for testing Deviation from Ideal Zero Order Release: An Orthodox Approach

Baggi Ravindra Babu*

Department of Pharmaceutics, Pulla Reddy Institute of Pharmacy, Hyderabad-502 313

*Corresponding Author E-mail: baggi.ravi39@gmail.com

Online published on 16 March, 2019.


The objective of this study was to develop Nicorandil floating tablets by melt granulation technique using almond gum as swellable plus retarding polymer and cetosteryl alcohol as waxy plus retarding polymer. Zero order of drug release is confirmed as drug release from the matrix tablets as it contain higher square of correlation coefficient (R2) than first order kinetics. Further, the drug release data (test) is checked for its deviation from an ideal release profile. The release profiles of the test formulation are slightly deviate the ideal zero order release profile.



Controlled release; Floating tablets; Zero order; Buoyancy; Area under curve.


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