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Asian Journal of Pharmacy and Technology
Year : 2018, Volume : 8, Issue : 3
First page : ( 182) Last page : ( 185)
Print ISSN : 2231-5705. Online ISSN : 2231-5713.
Article DOI : 10.5958/2231-5713.2018.00029.6

Toxicokinetics-A Review

Merlin N. J.*, Alfiya A. R., Dharan Shaiju S

Department of Pharmacology, Ezhuthachan College of Pharmaceutical Sciences, Marayamuttom, Trivandrum

*Corresponding Author E-mail: merlinbinu76@yahoo.co.in

Online published on 24 October, 2018.


Toxicokinetics (TK) is ‘the generation of pharmacokinetic data, either as an integral component in the conduct of non-clinical toxicity studies or in specially designed supportive studies, to assess systemic exposure. Physiologically based toxicokinetic [(PBTK), or alternatively referred to as physiologically based pharmacokinetic (PBPK)] models are quantitative descriptions of absorption, distribution, metabolism, and excretion of chemicals. Toxicokinetics, toxicodynamics and toxicogenomics (TK/TD/TG) methods are the potential tools in human health risk assessment.



Toxicokinetics, PBTK model, PBPK model, safety assessment, Drug development.


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