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Development and Evaluation of press coated tablets of Carvedilol using solid dispersion prepared by spray drying technique Raju Tina* DM WIMS College of Pharmacy, Naseera Nagar, Meppadi P.O., Wayanad, Kerala-673577 *Corresponding Author E-mail: tinarcpmht@gmail.com
Online published on 24 October, 2018. Abstract Carvedilol is a non-selective beta and alpha blocker which is insoluble in water. It is used in the treatment of mild to severe congestive heart failure (CHF) and high blood pressure. As the solubility is very poor the bioavailability is only 25–35%. The problem of poor solubility can be overcome using any of the physical or chemical methods of solubility enhancement. The purpose of this research was to improve the solubility of Carvedilol by spray drying technique using hydrophilic polymers β-Cyclodextrin and Plasdone-K30. Prepared solid dispersions were evaluated for drug content, saturation solubility and in-vitro drug release study. The compatibility and surface morphology was studied by Fourier Transforms Infrared spectroscopy (FTIR), Differential Scanning Calorimetry (DSC) and Scanning Electron Microscopy (SEM) respectively. The spray dried solid dispersions of Carvedilol were incorporated into press coated tablets and were subjected to various precompression and postcompression parameters. The effect of the various barrier layer compositions on the lag time was studied. This research emphasizes on the role of chronotherapy for treatment of hypertension. Top Keywords Carvedilol, pulsatile drug delivery, chronotherapy, lag phase, press-coated tablets. Top | |
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