Design and Development of Dental Film Containing Aloe vera for the Treatment of Human Periodontal Diseases Samal Himansu Bhusan1,*, Das Itishree Jogamaya1, Patra Ch. Niranjan2, Murthy P. N.3 1Department of Pharmaceutics, Guru Nanak Institutions Technical Campus-School of Pharmacy, Ibrahimpatnam, Hyderabad-501506, India 2Roland Institute of Pharmaceutical Sciences, Berhampur, Odisha-760010, India 3Royal College of Pharmacy and Health sciences, Berhampur, Odisha-760002, India *Corresponding Author E-mail: hbsamal@gmail.com
Online published on 29 January, 2016. Abstract This study was designed to develop and evaluate dental film containing Aloe Vera extracts for the treatment of Periodontitis. Aloe Vera shows wide spectrum of antibacterial activity against a number of periodontal pathogen and hence selected for site specific delivery for the treatment of Periodontitis. Aloe vera is formulated into dental films by solvent casting technique using polymers such as Ethyl cellulose, Carbopol 971P and HPMC K4M with PEG 4000 as plasticizer and prepared films (F1-F8) were evaluated for various properties such as weight variation, tensile strength, moisture loss, drug content, in-vitro drug release, In-vitro antibacterial and stability studies. In-Vitro dissolution studies showed an initial burst release to achieve immediate therapeutic level of drug in periodontal pocket followed by a progressive fall and extended release of the drug with more uniformity for prolonged period of time. Stability studies did not show any significant changes with respect to content and appearance. In-vitro experiments demonstrated that the prepared film F8 represent a suitable dosage form to release Aloe vera for 96 h and considered as the Optimized formulation. Top Keywords Aloe vera; local delivery; Periodontitis; Controlled Release. Top |