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Asian Journal of Pharmacy and Technology
Year : 2015, Volume : 5, Issue : 2
First page : ( 122) Last page : ( 126)
Print ISSN : 2231-5705. Online ISSN : 2231-5713.
Article DOI : 10.5958/2231-5713.2015.00019.7

Development of chemometric assisted methods for Simultaneous estimation of Ternary mixture of Telmisartan hydrochloride, Amlodipine besylate and Hydrochlorothiazide

Daharwal S. J.*, Singh Veena D.

University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur-492010, Chhattisgarh, India

*Corresponding Author E-mail: daharwalresearch@rediffmail.com

Online published on 29 October, 2015.


Telmisartan hydrochloride (TELM), Amlodipine besylate (AMLO), and Hydrochlorothiazide (HCTZ) are coformulated in a single-dose combination for the treatment of hypertensive patients whose blood pressure is not adequately controlled on either component monotherapy. In this work, chemometric method, classical least squares (CLS) was applied for simultaneous Spectrophotometric determination of TELM, AML and HCTZ in their combined pharmaceutical tablets. The optimum assay conditions were established and the proposed method was successfully applied for the assay of the ternary mixtures of drugs and combined pharmaceutical tablets with excellent recoveries. No interference was observed from common pharmaceutical additives. The results were favorably compared with those obtained by a reference HPLC method.



Telmisartan hydrochloride; Amlodipine besylate; Hydrochlorothiazide Spectrophotometry; chemometric method; Pharmaceutical tablets.


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