Neuroprotective activity of polyherbal formulation on colchicine induced alzheimer's disease in rat model Anawal Lingaraj*, Chandrashekar V M, Shalavadi Mallappa, Teli Shubham, Madalageri Manjunath, Sadashivanavar Veeresh, Patil Vidya, Kumbar Sakkoobayi, Horatti Prema Department of Pharmacology, BVVS Hanagal Shri Kumareshwar College of Pharmacy, Bagalkote, Karnataka, India *Corresponding Author E-mail: lingarajanawal@gmail.com
Online published on 10 April, 2025. Abstract Objective The current study was designed to study the neuroprotective effect of Polyherbal formulation against the Colchicine-induced Alzheimer’s disease rat model. Methods The memory enhancing activity of Polyherbal formulation was demonstrated by the intracerebroventricular administration of colchicine in Sprague-dawley rats. The effect of Polyherbal formulation were studied by evaluating the neurobehavioral assessment parameters like Morris water maze test, Locomotor activity, Open filed and Elevated plus maze test were performed at 0, 7, 14 and 28 days for assessing the cognitive and gross behavioral activities in all groups. Results and Discussion The effect of Polyherbal formulation shows a neuroprotective activity with significant (p<0.001) decrease in Mean transfer latency, Time spent in open arm, Number of entries in open arm, escape latency, number of ambulatory movement, latency, numbering of rearing, number of grooming, rest and significant (p<0.001) increase in time spent closed arm, number of entries in closed arm, Probe trail, time spent in platform quadrant and spontaneous locomotion, number of ipsilateral rotation. Conclusion In conclusion, the result of current study evidenced that the Polyherbal formulation (PHF) showed potent neuroprotective activity against colchicine induced Alzheimer’s disease. Top Keywords Colchicine, Hibiscus vitifolius, Convolvulus pluricaulis, Michelia champaca and Hibiscus abelmoschus. Top |