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Asian Journal of Pharmacy and Technology
Year : 2021, Volume : 11, Issue : 1
First page : ( 59) Last page : ( 65)
Print ISSN : 2231-5705. Online ISSN : 2231-5713.
Article DOI : 10.5958/2231-5713.2021.00010.6

Development and rheological properties evaluation of a burn healing ointment composed of pomegranate peels and beta-sitosterol using factorial design

Al-Absi Maher1,*, Faisal Abdu2, Alagbarri Safwan1, Al-Nowihi Mofeed2

1Faculty of Pharmacy, Sana’a University, Yemen

2Biology Department Faculty of Science, Sana’a University, Yemen

*Corresponding Author E-mail: ph.d_hmg@hotmail.com, mahir120@gmail.com

Online published on 27 April, 2021.


The present study was aimed to developed and optimized the formulation of ointment base by using factorial design includes composition for treating skin burns and wounds. The composition includes bees wax, seams seed oil, Beta-sitosterol and pomegranate peels extract. Methods: A 23 randomized full factorial design was utilized in the present study. The responses observed in this study were: Hardness, Viscosity and Spreadability (rheological properties. Pareto charts and main effects plots of each response were done to obtain a optimum proportion of ingredients. Results: The Ointment formulation of pomegranate peel extract significantly shows a good result in all the evaluation test parameters such as Hardness, viscosity and Spreadability. A multi-response prediction analysis was done to obtain the combined optimum that was used to formulate the final product with BW: VAS: SO to be 5: 1.5: 60. Therefore it was conclude that the formula run order 6 consider as a optimized formula with the appropriate rheological characteristics. Conclusion: The optimum formula for the ointment base properties were estimated using the statistical a multi-response prediction analysis, Pareto charts and main effects plots of responses. This ointment base with desired rheological properties can be used for for cosmetic and pharmaceutical usages. It can be concluded that the ointment base obtained with optimal rheological properties can be used for healing burns, scars and wounds applications.



Ointment, Beta sitosterol, Punica granatum, Pomegranate peel, Rheological properties, Factorial design.


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