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Asian Journal of Pharmacy and Technology
Year : 2021, Volume : 11, Issue : 1
First page : ( 41) Last page : ( 47)
Print ISSN : 2231-5705. Online ISSN : 2231-5713.
Article DOI : 10.5958/2231-5713.2021.00007.6

Design and optimization of clotrimazole emulgel by using various polymers

Latha AVS Madhu*, Dr. Kumar J N Suresh, Sojana N, Mounika N, Priyanka G, Venkatesh A

Department of Pharmaceutics, Narasaraopeta Institute of Pharmaceutical Sciences, Narasaraopeta, Andhra Pradesh, India

*Corresponding Author E-mail: satyamadhulatha@gmail.com

Online published on 27 April, 2021.

Abstract

Emulgel is one of the recent technologies in NDDS used for dual controlled release of emulsion and gel for topical use. The stability of emulsion is increased, when it is incorporated into gel. Clotrimazole is a broad spectrum antifungal agent, also a hydrophobic drug. It is difficult to formulate as topical delivery. So emulgel is one of the best approaches to incorporate hydrophobic drugs. The purpose of the present study was to develop and optimized the Clotrimazole emulgel using polymers like Carbopol 934 and HPMC K4M at different concentrations. The Preformulation studies were conducted by using FTIR studies, the prepared emulgels were evaluated in terms of physical appearance, measurement of pH, viscosity, spreadability, drug content and in vitro diffusion studies. In vitro drug release studies were performed up to 8hrs. Among all formulations F6 shows better releasing property. So F6 was proved as the best formulation among all. F6 containing HPMC K4M polymer in low concentration showed better releasing property when compared to formulations containing Carbopol 934. So it was suggested that the Clotrimazole emulgel have potential advantages when compared to other topical drug delivery systems for incorporating hydrophobic drugs and posses better activity and stability.

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Keywords

Topical drug delivery, Emulgel, Clotrimazole, Carbopol 934, HPMC K4M, In vitro diffusion studies.

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