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Asian Journal of Pharmacy and Technology
Year : 2021, Volume : 11, Issue : 1
First page : ( 27) Last page : ( 35)
Print ISSN : 2231-5705. Online ISSN : 2231-5713.
Article DOI : 10.5958/2231-5713.2021.00005.2

Design preparation and formulation of piroxicam solid dispersion

Suryawanshi Swapnil1,*, Sonawane Jyoti2, Shaikh Siddiqua3, Shaikh Habeeba3

1Deparment of Pharmaceutics, SND College of Pharmacy, Babulgoan, Yeola, Maharashtra, 423401

2Department of Quality Assurance, SND College of Pharmacy, Babulgoan, Yeola, Maharashtra, 423401

3Department of Medicinal Chemistry, SND College of Pharmacy, Babulgoan, Yeola, Maharashtra, 423401

*Corresponding Author E-mail: Shaikhsiddiqua356@gmail.com

Online published on 27 April, 2021.



Preparation of solid dispersion of drug with different water-soluble polymers/carriers or without the addition of sodium lauryl sulphate (SLS) as surfactant.

Methods and Materials

The Solvent evaporation method was used for the preparation of solid dispersion. Solid dispersion was prepared in five different drugs:carrier ratios (1:1, 1:2, 1:3, 1:4 and 1:5). The different material used for formatting the piroxicam was Poiroxicam solid dispersion, microcrystalline cellulose, sodium starch glycolate, hroxyl propyl methyl cellulose, magnesium stearate, talc. The dissolution profile is done by using 0.1 N HCl (pH 1.2) (volume 900ml, temperature 37±0.05°C). 5ml of sample at each sampling interval was withdrawn. After each sampling, sample withdrawn was replaced by same dissolution media kept in the control flask. The sample withdrawn was then immediately filtered and analyzed for sample content by UV spectrophotometer at 358nm after suitable dilutions. Stability study was done by for one month tablet samplewas analyzed for drug content & dissolution.

Results and Discussion

Solubility and dissolution of piroxicam could be significantly improved by solid dispersion technique. Fast dissolving tablets of piroxicam containing solid dispersion having less disintegration time, wetting time and greater drug release with required mechanical strength were prepared successfully.



Piroxicam, HPMC-LV, Microcrystalline cellulose, Dissolution, Improve solubility.


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