Design preparation and formulation of piroxicam solid dispersion
*Corresponding Author E-mail: Shaikhsiddiqua356@gmail.com
Preparation of solid dispersion of drug with different water-soluble polymers/carriers or without the addition of sodium lauryl sulphate (SLS) as surfactant.
Methods and Materials
The Solvent evaporation method was used for the preparation of solid dispersion. Solid dispersion was prepared in five different drugs:carrier ratios (1:1, 1:2, 1:3, 1:4 and 1:5). The different material used for formatting the piroxicam was Poiroxicam solid dispersion, microcrystalline cellulose, sodium starch glycolate, hroxyl propyl methyl cellulose, magnesium stearate, talc. The dissolution profile is done by using 0.1 N HCl (pH 1.2) (volume 900ml, temperature 37±0.05°C). 5ml of sample at each sampling interval was withdrawn. After each sampling, sample withdrawn was replaced by same dissolution media kept in the control flask. The sample withdrawn was then immediately filtered and analyzed for sample content by UV spectrophotometer at 358nm after suitable dilutions. Stability study was done by for one month tablet samplewas analyzed for drug content & dissolution.
Results and Discussion
Solubility and dissolution of piroxicam could be significantly improved by solid dispersion technique. Fast dissolving tablets of piroxicam containing solid dispersion having less disintegration time, wetting time and greater drug release with required mechanical strength were prepared successfully.
Piroxicam, HPMC-LV, Microcrystalline cellulose, Dissolution, Improve solubility.