Comparative study on treatment of rheumatoid arthritis
Gosavi Siddhesh1, Joshi Pranali2,*, Bhogate Vidur3, Gawade Sairaj3, Sangelkar Pooja3, Kanekar Shraddha3
1Yashwantrao Bhonsale College of Pharmacy, University of Mumbai, Maharashtra, India
2Department of Pharmaceutics, Yashwantrao Bhonsale College of Pharmacy, University of Mumbai, Maharashtra, India
3Yashwantrao Bhonsale College of Pharmacy, University of Mumbai, Maharashtra, India
*Corresponding Author E-mail: firstname.lastname@example.org
Online published on 27 April, 2021.
Rheumatoid arthritis is an autoimmune inflammatory disease which has affected almost 0.5-1% of total population in the world. It is the disease which causes inflammation in the joints due the attack of various inflammatory agent resulting in formation of antibody against body’s own self antigen. Various inflammatory mediators are activated during this immune response. Rheumatoid factor, tumor necrosis factor, peptidylargininedeiminase, Jak-STAT kinase are some of the major causes of rheumatoid arthritis. The main purpose of this work is to comparatively study various anti-arthritic drugs for their therapeutic dose, potency and their side effects, so that it will help in correct choice of medication to treat it. It will also provide most of the data related to treatment in a collaborated form. Different classes of drugs have been compared such as NSAIDS, Biologic and Non-biologic DMARDS, including adjuvants drugs. Nowadays combination therapy is also used which is also compared in this review article. All data related to combinations have been compiled by studying various articles and information from the books. Article also involves comparison of newer drugs and suggestion for which combination can be tried for better treatment of RA, based on study of drugs for their chemistry and compatibility.
Rheumatoid arthritis, Antirheumatoid drugs, Combination therapy, Mechanism of action, Adverse reactions.