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Asian Journal of Pharmacy and Technology
Year : 2021, Volume : 11, Issue : 1
First page : ( 1) Last page : ( 4)
Print ISSN : 2231-5705. Online ISSN : 2231-5713.
Article DOI : 10.5958/2231-5713.2021.00001.5

Synthesis of isoniazid from citric acid

Jadhav Rutuja T1,*, Bhosale Yashvardhan P2

1Dept of Pharmaceutical Chemistry, SND College of Pharmacy, Bhabhulgaon, Yeola

2Dept of Quality Assurance, Mahatma Gandhi Vidyamandir’s Pharmacy College, Nashik

*Corresponding Author E-mail: rutujatjadhav21@gmail.com

Online published on 27 April, 2021.


Isoniazid is an organic compound. It is a first line drug used in prevention and treatment of tuberculosis also Isoniazid has an anti-depressant effect. Isonicotin hydrazine is also known as isoniazid. A process was developed for the preparation of isoniazid from citric acid via citrazinic acid 2, 6-dichloroisonicotinic acid, isonicotinic acid and ethyl isonicotinate. Yields and procedures in all steps were improved (1).



Isoniazid, Citrazinic acid, Isonicotin, Anti-depressant, Tuberculosis.


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