(44.201.99.222)
Users online: 1885    [ij] [ij] [ij] 
Email id
 

Asian Journal of Pharmacy and Technology
Year : 2020, Volume : 10, Issue : 4
First page : ( 241) Last page : ( 244)
Print ISSN : 2231-5705. Online ISSN : 2231-5713.
Article DOI : 10.5958/2231-5713.2020.00040.9

Serum creatinine and eGFR are affected in female hypothyroid patients with poor Thyroid control

Dhivya S1, Gangopadhyay Sukanya2,*5, Kumar S Pradeep3, Sarkar Gautam4

1Senior Resident, Department of Biochemistry, VMMC and Safdarjung Hospital, New Delhi - 110029

2Associate Professor, Department of Biochemistry, VMMC and Safdarjung Hospital, New Delhi - 110029

5Ex-Assistant Professor, Department of Biochemistry, Subharti Medical College, Meerut, Uttar Pradesh - 250005

3Senior Resident, Department of GI Surgery, AIIMS, New Delhi - 110023

4Ex-Professor and Head, Department of Biochemistry, Subharti Medical College, Meerut, Uttar Pradesh - 250005

*Corresponding Author E-mail: sukanya.gangopadhyay@gmail.com

Online published on 27 April, 2021.

Abstract

Introduction

Hypothyroidism is a rising concern in India especially among women of all ages. Every year new cases are being diagnosed either independently or in combination with other medical and gynecological problems. With the further advent of our knowledge on hypothyroidism, it has been noticed that the renal function could be affected in such patients.

Aim and Objective

The aim of the present study was done to understand the effect of hypothyroidism on renal function in untreated or poorly treated hypothyroid subjects with the objective of comparing serum creatinine levels and estimated glomerular filtration rate (eGFR) in hypothyroid females with healthy age-matched controls.

Materials and Methods

Serum samples of 30 female patients received in our immunology lab with Thyroid Stimulating Hormone (TSH) more than 5mIU/L were analyzed for creatinine levels and the GFR was calculated concerning their age by using Modification of Diet in Renal Disease Study (MDRD) formula online. The same was repeated in 30 healthy female controls.

Results and Observations

The mean TSH value was significantly more in the cases (cases 8.15±2.5mIU/L; controls 3.11±0.88mIU/L; p-value < 0.0001) as purposefully high TSH samples were selected. Mean serum creatinine was significantly raised in the cases (cases 0.9±0.13mg/dl; controls 0.67±0.07mg/dl; p-value < 0.0001). The mean calculated GFR was 108.32±13.41mL/min/1.73m2 in controls whereas in cases it was significantly low at 77.19±13.36mL/min/1.73m2 (p-value < 0.0001).

Conclusion

The mean serum creatinine was on the higher side of the normal range and mean calculated GFR was low in untreated or poorly treated hypothyroid females in Meerut, Uttar Pradesh. Hypothyroid women should regularly undergo renal assessment as a precautionary measure.

Top

Keywords

Hypothyroidism, Estimated glomerular filtration rate (eGFR), Modification of Diet in Renal Disease Study (MDRD) formula, Serum creatinine.

Top

  
║ Site map ║ Privacy Policy ║ Copyright ║ Terms & Conditions ║ Page Rank Tool
596,893,539 visitor(s) since 30th May, 2005.
All rights reserved. Site designed and maintained by DIVA ENTERPRISES PVT. LTD..
Note: Please use Internet Explorer (6.0 or above). Some functionalities may not work in other browsers.