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Asian Journal of Pharmaceutical Research
Year : 2019, Volume : 9, Issue : 1
First page : ( 19) Last page : ( 21)
Print ISSN : 2231-5683. Online ISSN : 2231-5691.
Article DOI : 10.5958/2231-5691.2019.00004.2

The Correlation of Noise with Serum K+I 67 in the Organ of Corti of Rattus Norvegicus

Herwanto Yusa1, Ilyas Syafruddin2, Harahap Juliandi3

1Faculty Medicine, Universitas Sumatera, Utara

2Faculty Biologic and Mathematic, Universitas Sumatera, Utara

3Faculty Health and Community Medicine, Universitas Sumatera, Utara

Corresponding Author E-mail: yh67.yh@gmail.com

Online published on 15 March, 2019.


Noise according to Occupational Safety & Health Administration (OSHA, 2010) has safety limit not more than 85dB. Noise exposure, noise frequency, noise intensity and individual sensitivity to imunological enhancement in serum and response to repair the damaging of cohlea corti organ.


The study was a pure experimental study in vitro. The sample used in this study was the organ tissue corticcell membrane basilaris cohlea. The study were conducted in 2 stages, the first stage of the study wasexamination ofthe culture cell organ cortic which was basilar membrane, which had been treated by noise> 80 dB in the 5 treatment groups. The second stage of the study was immunohistochemical Ki67 examination in cochlear tissue into the treatment groups.


Analysis of ANOVA showed that there was significant difference for the level KI67. The lowest mean of Ki67 was found in group rats control with mean of 0.09 (SD = 0.009) and the highest was found in the group P5 which received treatment noise 80–110 dB with mean 0, 41 (SD = 0.07). The results by using Anova test showed that there was significant mean (p <0.001) for the level HSP 70 between the group P0 to group P5. The lowest mean HSP 70 was found in the control rats group with mean 2.79 (SD = 0.43) and the highest in the rats group which was given treatment noise 80–110 dB with mean of 17.08 (SD = 3.22).


Ki67 had significant positive correlation which very strong (r = 1) with HSP70. All the group of rats showed that the similar result in the study (Hu et al, 2009; Makishima et al., 2011; Herwanto, 2014) which strongly related to apoptosis in the internal mitochondria in the cochlea



Noise, organ cortic, serum Ki67, Immunohistochemistry.


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