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Asian Journal of Pharmaceutical Research
Year : 2018, Volume : 8, Issue : 4
First page : ( 241) Last page : ( 242)
Print ISSN : 2231-5683. Online ISSN : 2231-5691.
Article DOI : 10.5958/2231-5691.2018.00041.2

Calanolide A New Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI): A Review

Mr. Jain Mayur S.*, Dr. Barhate Shashikant D., Mr. Gayakwad Bhushan P.

Shree Sureshadada Jain Institutes of Pharmaceutical Education and Research, Jammer, Maharashtra (India)

*Corresponding Author E-mail: mayurjain176@gmail.com

Online published on 25 December, 2018.


Calanolide A is a new non-nucleoside reverse transcriptase inhibitor (NNRTI) derived from a plant found in the Malaysian rain forest. A related compound, calanolide B, also has anti-HIV activity. Both drugs are being developed by Sarawak Pharmaceuticals. A preliminary dosing study among HIV-infected individuals showed a significant antiviral effect compared with placebo. Calanolide A is a compound isolated from the latex of the tree, Calophyllum lanigerum (var. austrocoriaceum), that grows in the rain forest of the Malaysian state of Sarawak on the island of Borneo.



Calanolide A, Anti-HIV activity, Reverse transcriptase inhibitor.


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