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Calanolide A New Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI): A Review Mr. Jain Mayur S.*, Dr. Barhate Shashikant D., Mr. Gayakwad Bhushan P. Shree Sureshadada Jain Institutes of Pharmaceutical Education and Research, Jammer, Maharashtra (India) *Corresponding Author E-mail: mayurjain176@gmail.com
Online published on 25 December, 2018. Abstract Calanolide A is a new non-nucleoside reverse transcriptase inhibitor (NNRTI) derived from a plant found in the Malaysian rain forest. A related compound, calanolide B, also has anti-HIV activity. Both drugs are being developed by Sarawak Pharmaceuticals. A preliminary dosing study among HIV-infected individuals showed a significant antiviral effect compared with placebo. Calanolide A is a compound isolated from the latex of the tree, Calophyllum lanigerum (var. austrocoriaceum), that grows in the rain forest of the Malaysian state of Sarawak on the island of Borneo. Top Keywords Calanolide A, Anti-HIV activity, Reverse transcriptase inhibitor. Top | |
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