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Asian Journal of Pharmaceutical Research
Year : 2018, Volume : 8, Issue : 4
First page : ( 241) Last page : ( 242)
Print ISSN : 2231-5683. Online ISSN : 2231-5691.
Article DOI : 10.5958/2231-5691.2018.00041.2

Calanolide A New Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI): A Review

Mr. Jain Mayur S.*, Dr. Barhate Shashikant D., Mr. Gayakwad Bhushan P.

Shree Sureshadada Jain Institutes of Pharmaceutical Education and Research, Jammer, Maharashtra (India)

*Corresponding Author E-mail: mayurjain176@gmail.com

Online published on 25 December, 2018.

Abstract

Calanolide A is a new non-nucleoside reverse transcriptase inhibitor (NNRTI) derived from a plant found in the Malaysian rain forest. A related compound, calanolide B, also has anti-HIV activity. Both drugs are being developed by Sarawak Pharmaceuticals. A preliminary dosing study among HIV-infected individuals showed a significant antiviral effect compared with placebo. Calanolide A is a compound isolated from the latex of the tree, Calophyllum lanigerum (var. austrocoriaceum), that grows in the rain forest of the Malaysian state of Sarawak on the island of Borneo.

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Keywords

Calanolide A, Anti-HIV activity, Reverse transcriptase inhibitor.

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