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Asian Journal of Pharmaceutical Research
Year : 2018, Volume : 8, Issue : 4
First page : ( 205) Last page : ( 214)
Print ISSN : 2231-5683. Online ISSN : 2231-5691.
Article DOI : 10.5958/2231-5691.2018.00035.7

Development and Evaluation of Telmisartan Pulsatile Drug Delivery by using Response Surface Methodology

Patil Indrajeet S.*, Patil Omkar A., Mandake Girish Chandra R., Nitalikar Manoj M.

Department of Pharmaceutics, Rajarambapu College of Pharmacy, Kasegaon-415404, Dist-Sangli, Maharashtra, India

*Corresponding Author E-mail: indarp1993@gmail.com

Online published on 25 December, 2018.

Abstract

The aim of present study was to develop, evaluate and optimize the pulsincap formulation on the principle based on the pulsatile drug delivery system using Telmisartan drug. Telmisartan is mainly used for treatment of high blood pressure, congestive heart failure, and to increase the chances of living longer after a heart attack. It is an angiotensin II receptor antagonist that is selective for the type I angiotensin receptor. Formalin treatment has been employed to modify the solubility of gelatin capsules. Quantitative test for formaline residue was carried out. FTIR study shown drug and excipient are compatible with each other. Hydrogel plug of various components are prepared and used in pulsincap formulation. The drug content of the formulated pulsincap was found to be in the range 92.65 to 101%. In vitro drug release study in pH 1.2 buffer was zero percent and capsule was intact for first 2 hrs. F8 formulation batch was selected as best formulation as F8 batch released maximum drug in pH 7.4 phosphate buffer than other formulation batches. In the present work an attempt has been made to develop, evaluate and optimize a time or site specific pulsatile drug delivery system of drug Telmisartan.

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Keywords

Pulsatile, Pulsincap, Telmisartan, Hypertension, Response surface methodology.

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