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Asian Journal of Pharmaceutical Research
Year : 2016, Volume : 6, Issue : 3
First page : ( 191) Last page : ( 200)
Print ISSN : 2231-5683. Online ISSN : 2231-5691.
Article DOI : 10.5958/2231-5691.2016.00028.9

Significance of Pharmaceutical Excipients on Solid Dosage form Development: A Brief Review

Somnache Sandesh Narayan1,*, Godbole Ajeet Madhukar1, Gajare Pankaj Sadashiv1, Kashyap Sapna2

1Department of Pharmaceutics, PES'S Rajaram and Tarabai Bandekar College of Pharmacy, Farmagudi, Ponda-403401, Goa, India

2Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Uttar Pradesh, India

*Corresponding Author E-mail: sandeshsomnache@gmail.com

Online published on 18 October, 2016.


The rapid and vibrant growth of pharmaceutical industries leads to newer challenges in field of formulation development. With the launch of new Active Pharmaceutical Ingredients and also the excipient possessing different physicochemical properties, it is really a challenging task for a formulation scientist in presenting a viable, suitable and stable dosage formulation. Many failures in pharmaceutical formulation manufacturing processes are caused due to issues related to Pharmaceutical excipients. Selection of wrong excipient not only affects the physicochemical properties of dosage form but also affect the biopharmaceutical characters. Along with drug excipient incompatibilities, improper ratio of excipients, particle characters including molecular and bulk characters of excipients affect the dosage form characters. Thus in current review, the significance of various properties of excipient on the physicochemical and biological behavior of dosage form and the criteria for selection of excipients in designing of robust formulation is summarized. Disintegrating agents and lubricating agents are the excipients, although required in very small proportion, but their physicochemical characters and ratio in formulation highly affects the formulation properties. Thus, in current review special emphasis is given on the effect of disintegrating agents and lubricating agents on the characteristics of tablet dosage form.



Inert pharmaceutical Ingredient, Selection Criteria, Functionality of excipients, Disintegrating Agents, Lubrication Agents.


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