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Estimation of Levocetirizine in Bulk and Formulation by Second Order Derivative Area under Curve UV-Spectrophotometric Methods Mali Audumbar Digambar*, Patil Manojkumar Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, MS, India *Corresponding Author E-mail: maliaudu442@gmail.com
Online published on 8 December, 2015. Abstract Simple, fast and reliable spectrophotometric methods were developed for determination of Levocetirizine in bulk and pharmaceutical dosage forms. The solutions of standard and the sample were prepared in Methanol. The quantitative determination of the drug was carried out using the second order Derivative Area under Curve method values measured at 247-255nm. Calibration graphs constructed at their wavelengths of determination were linear in the concentration range of Levocetirizine using 5–25μg/ml (r2=0.999) for second order Derivative Area under Curve spectrophotometric method. The proposed methods have been extensively validated as per ICH guidelines. There was no significant difference between the performance of the proposed methods regarding the mean values and standard deviations. The developed methods were successfully applied to estimate the amount of Levocetirizine in pharmaceutical formulations. Top Keywords Levocetirizine, Second order Derivative, Area under Curve (AUC), Precision, Accuracy. Top | |
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