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Development of classical least square method for the determination of Candesartan and Hydrochlorthiazide in tablet dosage form Daharwal S. J.*, Singh Veena D. University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur-492010, Chhattisgarh, India *Corresponding Author E-mail: daharwalresearch@rediffmail.com
Online published on 29 October, 2015. Abstract A new simple spectrophotometric method was developed for the determination of binary mixtures of Candesartan cilexetil (CAND) and Hydrochalorothiazide (HCTZ), without prior separation. The method is based on the multi-wavelength technique i.e. classical least square (CLS) method. The tablet is determined by the multi-wavelength technique (CLS), at the wavelengths range of 215–225 nm over the concentration ranges of 2.5–50 and 1–30 μg/mL with mean recovery more than 98% for both drugs CAND and HCTZ, respectively. The proposed spectrophotometric method was validated and successfully applied for the assay of drug combination in several laboratory-prepared mixtures and commercial tablets. Top Keywords Spectrophotometric analysis; Classical least square method; Candesartan; Hydrochlorothiazide. Top | |
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