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Asian Journal of Pharmaceutical Research
Year : 2013, Volume : 3, Issue : 4
First page : ( 159) Last page : ( 165)
Print ISSN : 2231-5683. Online ISSN : 2231-5691.

Design, Synthesis and anti microbial, anti-inflammatory, Antitubercular activities of some 2,4,5-trisubstituted imidazole derivatives

Kalkotwar R. S.1,*, Saudagar R. B.2

1Department of Pharmaceutical Sciences, Bhagwant University, Ajmer, Rajashthan, India

2Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Nashik, M.S., India

*Corresponding Author E-mail: rsk_55@rediffmail.com

Online published on 18 June, 2014.

Abstract

A Novel Series of Some 2,4,5-trisubstituted imidazole derivatives were prepared with the aim to get better antibacterial activity, antifungal activity, antitubercular and anti-inflammatory activity. The structures of synthesized compounds were supported by means of IR, 1H NMR. Title compounds were evaluated for antibacterial activity, antifungal activity, antitubercular and anti-inflammatory activities. Among the synthesized compounds some compounds found to possess all these activities. The QSAR study for anti-inflammatory activity shows good results.

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Keywords

QSAR, Antibacterial, antifungal, anti-inflammatory activity.

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