(3.236.121.117)
Users online: 2320    [ij] [ij] [ij] 
Email id
 

Asian Journal of Pharmaceutical Research
Year : 2021, Volume : 11, Issue : 1
First page : ( 29) Last page : ( 38)
Print ISSN : 2231-5683. Online ISSN : 2231-5691.
Article DOI : 10.5958/2231-5691.2021.00007.1

SGLT-2 inhibitors-hope or hype? -an updated review

Dr. Kumar R. Santhosh*

JSS College of Pharmacy, Rocklands, Ooty, 643001

*Corresponding Author E-mail: santhosh@jssuni.edu.in

Online published on 27 April, 2021.

Abstract

Objective

This literature review aims to identify and investigate existing evidence about sodium-glucose cotransporter 2 (SGLT-2) inhibitors.

Evidence Acquisition

A literature search in PubMed and google scholar (January 1998 to April 2020) was done. Search terms like “(SGLT-2) inhibitors,” “pharmacokinetic,” “efficacy,” “cardiovascular safety,” and all the drug names of this class and its combination were included. Diabetes mellitus has been the silent killer of mankind, Metformin has been the reliable warrior for 62 years since its approval, and remains to be the first-line drug based on their beneficial effects.

Conclusion

In 2015, the American Diabetes Association reported that data on microvascular and macrovascular results were unavailable for almost all the newer antidiabetic agents, which resulted in placing SGLT inhibitors as second-or third-line agents, Ever since, new evidence has emerged, notably for SGLT2 inhibitors, which have inspired and influenced physicians to reconsider their approach towards glucose reduction in type 2 diabetes. Hence a consolidated review on safety and efficacy of the drug is the need of the hour.

Top

Keywords

Sodium-glucose cotransporter, Diabetes, Cardiovascular safety.

Top

  
║ Site map ║ Privacy Policy ║ Copyright ║ Terms & Conditions ║ Page Rank Tool
598,076,638 visitor(s) since 30th May, 2005.
All rights reserved. Site designed and maintained by DIVA ENTERPRISES PVT. LTD..
Note: Please use Internet Explorer (6.0 or above). Some functionalities may not work in other browsers.