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Asian Journal of Pharmaceutical Research
Year : 2021, Volume : 11, Issue : 1
First page : ( 13) Last page : ( 16)
Print ISSN : 2231-5683. Online ISSN : 2231-5691.
Article DOI : 10.5958/2231-5691.2021.00004.6

Development and validation of uv spectrophotometric method for estimation of itraconazole in bulk drug and solid dosage form

Chavan Pavan, Bandgar Sandip*, Gejage Santosh, Patil Sagar, Patil Shitalkumar

Department of Pharmaceutics, Ashokrao Mane College of Pharmacy Peth-Vadgaon, (Kolhapur), Maharashtra, 416112

*Corresponding Author E-mail: bandgarsandip21@gmail.com

Online published on 27 April, 2021.


A simple, robust, reliable, and economical method for Itraconazole as UV spectrophotometric estimation in bulk and tablet dosage form was developed using the method of absorbance ratio and validated according to the ICH guidelines. In the present analysis, Itraconazole was calculated using the absorbance values at 262 nm. The findings of the study were statistically checked for Linearity, precision, exactness, LOD and LOQ. The procedure was found to be linear in the concentration range of 2-14μg/ml through a 99.40 per cent Itraconazole recovery. The results of the validation parameters also showed that the proposed method was found to be effective, precise, reproducible, responsive and suitable for regular quality assurance analyzes for Itraconazole in bulk and solid estimation.



Itraconazole, Absorbance ratio method, LOD and LOQ, ICH guidelines.


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