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Asian Journal of Pharmaceutical Research
Year : 2020, Volume : 10, Issue : 4
First page : ( 312) Last page : ( 318)
Print ISSN : 2231-5683. Online ISSN : 2231-5691.
Article DOI : 10.5958/2231-5691.2020.00053.2

Review on non effervescent gastro retentive drug delivery systems-microballons

Ayalasomayajula Lakshmi Usha*, Navya Karumoju, Earle Radha Rani, Pravallika Andra A S E

Department of Pharmaceutics, Maharajah’s College of Pharmacy, Vizianagaram, Andhra Pradesh, India

*Corresponding Author E-mail: alakshmiusha@gmail.com

Online published on 27 April, 2021.

Abstract

Microballoons is a novel technology of pharmaceutical field in the floating drug delivery for achieving gastric retention. Microballoons are gastro retentive drug delivery systems that are based on the non-effervescent approach. Generally microballoons are in spherical shape without a core. These microballoons are free flowing powder which consists of protein and synthetic polymers and the size ranges from 200 μm. These microballoons are low density systems which have sufficient buoyancy to float over the gastric fluid for prolonged period of time without any irritation to gastrointestinal tract. Microballoons are prepared by using different techniques such as simple solvent evaporation method, double emulsion method, phase separation coacervation method, polymerization method, spray drying method, spray congealing method and hot melt encapsulation method.

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Keywords

Non Effervescent Gastro Retentive Drug Delivery Systems, Conventional oral dosage, Fluctuations.

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