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Asian Journal of Pharmaceutical Research
Year : 2020, Volume : 10, Issue : 1
First page : ( 08) Last page : ( 12)
Print ISSN : 2231-5683. Online ISSN : 2231-5691.
Article DOI : 10.5958/2231-5691.2020.00002.7

Dissolution Rate Enhancement of Ramipril by Solid Dispersion Technique

Mr. Vakhariya Rohan R.*, Kumbhar S. M., lade R. B., Salunkhe P. S., Ubale R. H.

Rajarambapu College of Pharmacy, Kasegaon, Tal.-Walwa, Dist.-Sangli, Maharashtra

*Corresponding Author E-mail: rohanwakhariya@gmail.com

Online published on 3 June, 2020.

Abstract

Solubility enhancement of poorly aqueous soluble drugs is an important aspect of formulation development. Dissolution of drug is rate determining step for oral absorption of poorly watersoluble drugs, which consequently affect the in-vivo absorption of drug. Ramipril is a poorly watersoluble drug and it also has poor bioavailability. Therefore, many strategies have been worked out to develop its aqueous solubility as well as its release rate from various solid dosage forms. In the present study, the solid dispersion technique was evaluated for enhancement of solubility and dissolution rate. In present study solid dispersion was prepared by using two different polymers i.e. ß-cyclodextrin, Hydroxypropyl cellulose and there combination also with different drug-carrier ratios was evaluated for the enhancement of solubility and dissolution rate as well as flowability, compressibility of Ramipril. The solid dispersions were characterized by UV Spectroscopy, In Vitro Drug Release, etc.

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Keywords

Solubility, Ramipril, ß-cyclodextrin, Solid Dispersions.

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