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Asian Journal of Pharmaceutical Analysis
Year : 2019, Volume : 9, Issue : 3
First page : ( 118) Last page : ( 122)
Print ISSN : 2231-5667. Online ISSN : 2231-5675.
Article DOI : 10.5958/2231-5675.2019.00022.X

RP-HPLC Method for Estimation of Solifenacin Succinate in API and Tablet Dosage Form

Bhavana V, Kumar Hemant T*, Rao Srinivasa Y, Rao Vara Prasad K

Department of Pharmaceutical Analysis and Quality Assurance, Vignan Institute of Pharmaceutical Technology, Beside VSEZ, Duvvada, Visakhapatnam-530049

*Corresponding Author E-mail: hemkar_pharma@yahoo.co.in

Online published on 31 December, 2019.

Abstract

A simple RP-HPLC method was developed and validated for the quantitative estimation of Solifenacin succinate in API and Tablet dosage form. In this method, mobile phase was Acetonitrile and water in the ratio of 80: 20% v/v and at a flow rate of 1.0 ml/min. The optimum wavelength for detection was 225 nm. The column used was Enable ODS reverse phase (250 mm × 4.6 mm, 5 μm particle size) C18 column. The retention time of solifenacin succinate was found at 2.92 min. The linearity was observed in the range of 10–100 μg/ml with the correlation coefficient of 0.998. The proposed method was found to be simple, precise, accurate and selective and can be successfully applied for the routine analysis of Solifenacin succinate in API and tablet dosage form without any interference by the excipients.

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Keywords

Solifenacin Succinate, RP-HPLC, Validation, Tablet dosage form.

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