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Asian Journal of Pharmaceutical Analysis
Year : 2019, Volume : 9, Issue : 2
First page : ( 45) Last page : ( 48)
Print ISSN : 2231-5667. Online ISSN : 2231-5675.
Article DOI : 10.5958/2231-5675.2019.00010.3

Eco-Friendly Spectrophotometric Estimation of Gliclazide using Hydrotropic Solubilization Technique

Kumar G Satheesh1,*, Kumar D Ajay2, Babu M Niranjan1, Debnath Subhashis1, Ishwarya B2, Jyothi G2, Kumar D Shravan2, Bhavani P2, Anjiah D2, Kumar G Sandeep2

1Department of Pharmaceutical Chemistry, Seven Hills College of Pharmacy, Venkatramapuram, Tirupati, Chittoor District, Andhra Pradesh-517561

2Department of Pharmaceutical Chemistry, Jyothishmathi College of Pharmacy, Turkapally (V), Shamirpet, (M) Medchal District, Telangana-500101

*Corresponding Author E-mail: gskpharma11@gmail.com

Online published on 3 July, 2019.


In the projected analysis work, a successful; attempt was made to develop simple, accurate, novel, ecofriendly and precise technique for the estimation of poorly water soluble drug Gliclazide in single drug containing dosage form. In the present investigation, a mixed hydrotropic blend of 2M urea and 6M trisodium citrate was used for quantitative determination. Gliclazide showed λ-max at 225 nm and beer's law was obeyed with in the concentration range of 4μg/ml-12μg/ml with mean recovery ranging from 95.33% to 96.35%. The developed technique was validated as per ICH guidelines.



Gliclazide, Urea, Trisodium citrate, Hydrotropy.


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