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Asian Journal of Pharmaceutical Analysis
Year : 2019, Volume : 9, Issue : 1
First page : ( 8) Last page : ( 10)
Print ISSN : 2231-5667. Online ISSN : 2231-5675.
Article DOI : 10.5958/2231-5675.2019.00003.6

Ecofriendly Validated Spectrophotometric Method for the Estimation of Amlodipine Besylate by using Hydrotropic Solubilization Method

Waghmare Akshay1, Taware Ganesh2, Baokar Shrikrishna1,*, Undare Santosh3

1Department of Pharmaceutical Chemistry, SVPM'S College of Pharmacy, Malegaon (Bk), Tal-Baramati, Dist-Pune, Maharashtra-413115

2Department of Pharmaceutics, SVPM'S College of Pharmacy, Malegaon (Bk), Tal-Baramati, Dist-Pune, Maharashtra-413115

3PG Department of Chemistry, Balbhim Arts, Science and Commerce College, Beed, Maharashtra-431122

*Corresponding Author E-mail:

Online published on 15 March, 2019.

Abstract

Simple sensitive and accurate spectrophotometric methods were developed for determination of poorly water soluble Amlodipine Besylate in pure and pharmaceutical dosage form using hydrotropic agents ammonium acetate. Hydrotropy is a good choice for replacing organic solvents used for this kind of drugs to reduce the cost and hazards of the analytical method. Amlodipine Besylate shows maximum absorption at 362 nm in 0.5 M of the hydrotropic agents. Beer's law was found to be obeyed in the concentration range of 5–25 μg/mL for the hydrotrope. Limit of detection was found to be 1.102μg/mL and limit of quantification was 3.278 μg/mL for ammonium acetate. The results were in a good agreement with those obtained with official USP method.

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