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Asian Journal of Pharmaceutical Analysis
Year : 2019, Volume : 9, Issue : 1
First page : ( 1) Last page : ( 4)
Print ISSN : 2231-5667. Online ISSN : 2231-5675.
Article DOI : 10.5958/2231-5675.2019.00001.2

Validated Derivative Spectrophotometric method for simultaneous estimation of Levocetirizine Dihydrochloride and Phenylephrine Hydrochloride from tablet formulations

Dyade G. K.*

SVPM's College of Pharmacy, Malegaon (BKII), Baramati, Dist. Pune-413115

*Corresponding Author E-mail: dyadegk@gmail.com

Online published on 15 March, 2019.

Abstract

A simple, precise and accurate spectrophotometric method was developed for simultaneous estimation of LevocetirizineDiHCl and Phenylephrine HCl in bulk and tablet dosage form. This method is based on use of derivative method for simultaneous estimation of both the drug from tablet using distilled water as solvent. Phenylephrine HCl shows maximum absorption at 273 nm and LevocetirizineDiHCl shows absorption at 231 nm. Phenylephrine HCL and Levocetirizine HCl obeys Beer’, s law in the concentration range 0–40 μg/ml and 030μg/ml respectively. During estimation of Tablet no interference was found from excipients. The dosage form contains 10 mg Phenylephrine HCl and 5 mg LevocetirizineDiHCl. The suitability of this method for estimation of both drugs was proved by validation. Statistical analysis of data shows that the developed method is sound under analytical condition and can be used for routine analysis of both drugs.

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Keywords

Phenylephrine HCl (PHE), LevocetirizineDiHCl (CET), Validation, Ultraviolet (UV), Nanometer(nm), Concentration (Conc.).

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