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Application of Normal and Reversed-Phase TLC/Densitometry Methods for Determination of Naratriptan Hydrochloride in Tablet dosage form Shirkhedkar Atul A.*, Borse Jayshri S., Patil Manoj D., Patil Amod S. Department of Pharmaceutical Chemistry, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, (M.S.), India, 425 405 *Corresponding Author E-mail: atulshirkhedkar@rediffmail.com
Online published on 7 July, 2018. Abstract Naratriptan Hydrochloride (NTPH) is used as antimigraine drugs. In the present investigations two simple, economical and precise, normal-phase High-Performance Thin-Layer Chromatography (Method A) and Reversed Phase High Performance Thin Layer Chromatography (Method B) have been established for determination of NTPH in bulk and in tablets. Method A and Method B were developed on aluminium plates precoated with silica gel 60F254 and RP-18 silica gel 60 F254 S as the stationary phase, respectively. Separation of NTPH was achieved using Chloroform: 2-propranol: triethylamine (8: 1.4: 0.6 v/v) in Method A and methanol: water: triethylamine (9: 0.6: 0.4 v/v) in Method B. Densitometry scanning were performed at 223 nm. Both methods were found to give compact spot for the NTPH at Rf 0.55 ± 0.02. Validation of Method A and Method B were performed as per as International Conference on Harmonization guidelines. Top | |
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