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Asian Journal of Pharmaceutical Analysis
Year : 2018, Volume : 8, Issue : 2
First page : ( 83) Last page : ( 85)
Print ISSN : 2231-5667. Online ISSN : 2231-5675.
Article DOI : 10.5958/2231-5675.2018.00016.9

Method Development and Validation of Cilazapril in Bulk Formulation by FC Reagent

Dagar Chavi*, Reddy G. Rohit, Ramesh T.

Department of Pharmaceutical Analysis and Quality Assurance, Vishnu Institute of Pharmaceutical Education and Research, Vishnupur, Narsapur, Medak, Telangana, India

*Corresponding Author E-mail:

Online published on 7 July, 2018.

Abstract

A simple, sensitive, accurate, precise and economical visible Spectrophotometric method was developed and validated for the estimation of Cilazapril in Bulk form. The method is based on the reaction of Cilazapril with FC Reagent [Folin Ciocalteu] in the presence of Sodium Carbonate producing blue colour which shows maximum absorbance at 725nm against reagent blank. The Chromogen obeyed Beer's law in the concentration range of 10–50 μg/ml for Cilazapril. The results of the analysis have been validated statistically and recovery studies.

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Keywords

Cilazapril, FC Reagent, Sodium Carbonate, Visible Spectrophotometric.

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