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Asian Journal of Pharmaceutical Analysis
Year : 2018, Volume : 8, Issue : 2
First page : ( 78) Last page : ( 82)
Print ISSN : 2231-5667. Online ISSN : 2231-5675.
Article DOI : 10.5958/2231-5675.2018.00015.7

RP-HPTLC Method for Determination of Garenoxacin mesylate in Bulk and in Tablet Formulation

Edlabadkar A. P.1, Rajput A. P.2,*

1Z. B. Patil Arts, Science and Commerce College, Deopur, Dhule (MS) India, 424002, aboliedlabadkar@gmail.com

2Arts, Commerce and Science College, Bodwad, Dist. Jalgaon (MS) India, 425310

*Corresponding Author E-mail: aprajput@rediffmail.com

Online published on 7 July, 2018.


Garenoxacin mesylate is used as an antifungal agent. A new, rapid, simple, economical and environmental friendly Reversed-Phase High-Performance Thin-Layer Chromatography (RP-HPTLC) has been developed and validated for quantitative determination of Garenoxacin mesylate in bulk and in tablet formulation. RP-HPTLC separation was performed on aluminum plates precoated with silica gel 60 RP-18 F254S as the stationary phase using n-butanol: methanol: triethylamine (60: 20: 20% v/v/v) as mobile phase. Quantification was done by densitometric analysis at 257 nm over the concentration range of 100 give compact and well resolved band for Garenoxacin mesylate at retention factor (Rf) 0.62 ± 0.02. The linear regression analysis data for calibration graph showed good linear relationship with r2 validated for precision, recovery, robustness, ruggedness and sensitivity Harmonization (ICH) guidelines. The Limit of Detection (LOD) and Limit of Quantification (LOQ) were found to be 6.63 ng and 20.11 ng, respectively. The proposed developed RP-HPTLC method identification and quantitative determination of Garenoxacin mesylate in bulk and in tablet formulation.



Garenoxacin mesylate, HPTLC, Validation.


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