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Asian Journal of Pharmaceutical Analysis
Year : 2018, Volume : 8, Issue : 1
First page : ( 25) Last page : ( 32)
Print ISSN : 2231-5667. Online ISSN : 2231-5675.
Article DOI : 10.5958/2231-5675.2018.00005.4

Development and Validation of UV Spectrophotometry and RP-HPLC Method for simultaneous determination of Rosuvastin and Clopidogrel in Tablet Dosage Form

Telrandhe Roshan*

Kamla Nehru College of Pharmacy, Butibori, Nagpur, 441108, Maharashtra, India

*Corresponding Author E-mail:

Online published on 2 June, 2018.


The aimed of research the method development and validation by UV spectrophotometry and RP HPLC method of the Rosuvastatin calcium and Clopidogrel bisulphate. The method is a simple, accurate, specific, precise, reproducible and sensitive. The λ max of ROSU and CLOP was found to be 240nm. The coefficient correlation 0.999, the Beer's Law limit 50–150 μg/ml, from the four trial of different concentration of mobile phase was selected Methanol: Water 80: 20 v/v, pH 3.0 at 240nm, flow rate 1ml/min, sample inlet 20 μL, C 18 Prontosil, %RSD of ROSU 1.017 and CLOP 0.173, theoretical plates ROSU 7797.53 and ROSU 8257.53, Retention time of ROSU 3.483min and CLOP 4.983min, Tailing factor ROSU 1.1787 and CLOP 1.074, limits 2 NMT, Accuracy ROSU 0.37% RSD, Recovery 99.59% and CLOP 0.18%RSD, recovery 100.41% was show good efficacy and results. The methods indicate future scope in analysis quality control of the estimation of ROSU and CLOP for routine drug quality analysis investigation.



UV Spectrophotometry, RP HPLC, Rosuvastatin calcium, Clopidogrel bisulphate, Simultanious estimation, validation.


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