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Asian Journal of Pharmaceutical Analysis
Year : 2017, Volume : 7, Issue : 4
First page : ( 214) Last page : ( 217)
Print ISSN : 2231-5667. Online ISSN : 2231-5675.
Article DOI : 10.5958/2231-5675.2017.00034.5

Synthesis of 2-(3-Substitutedamino-2, 4-Dithiobiuretoformamidino-4-isobutoxyphenyl)-4-Methyl-5-Carboxy-1, 3-Thiazoles

Shendge A. S., Tayade D. T.*, Kale P. R.

Department of Chemistry, Government Vidarbha Institute of Science and Humanities, Amravati, 444604

*Corresponding Author E-mail: anilsphd@gmail.com, skdtayade@mail.com

Online published on 2 June, 2018.

Abstract

A novel method has been developed for the synthesis of 2-(3-substitutedamino-2, 4-dithiobiuretoformamidino-4-isobutoxyphenyl)-4-methyl-5-carboxy-1, 3-thiazoles by the reaction of 2-(3-substitutedthioamidoformamidino-4isobutoxyphenyl)-4-methyl-5-carboxy-1, 3-thiazoles with substituted isothiocyanate in 60% ethanol-acetone. The method provides rapid and easy access to compounds in good yields by using 60% ethanol-acetone medium.

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Keywords

2-(3-Substitutedthioamidoformamidino-4-isobutoxyphenyl)-4-methyl-5-carboxy-1, 3-thiazoles, ethanol, acetone.

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