[ij] [ij] [ij] 
Email id

Asian Journal of Pharmaceutical Analysis
Year : 2017, Volume : 7, Issue : 2
First page : ( 117) Last page : ( 123)
Print ISSN : 2231-5667. Online ISSN : 2231-5675.
Article DOI : 10.5958/2231-5675.2017.00019.9

Development and validation of UV spectrophotometric method for Simultaneous estimation of Empagliflozin and Metformin hydrochloride in bulk drugs

Patil Sushil D.*, Chaure Sayali K., Kshirsagar Sanjay

MET's Institute of Pharmacy, MET League of Colleges, Bhujbal Knowledge City, Adgaon, Nashik, MS 422003

*Corresponding Author E-mail: sushilpharma@rediffmail.com

Online published on 18 September, 2017.


A new, simple, accurate and sensitive UV-spectrophotometric absorption correction method has been developed for simultaneous determination of Metformin HCl and Empagliflozin in bulk utilizing concept of standard addition. The method is based upon determination of Empagliflozin at 224 nm & Metformin HCl at 230 nm methanol as a solvent. Overlay spectra of both drugs shows absorbance at 227 nm. Linearity was observed in range of 10–50 μg/ml and 1–3 μg/ml for Metformin HCl and Empagliflozin respectively. The correlation coefficient value was found to near to 1. All methods were statistically validated as per ICH guidelines.



Metformin HCl, Empagliflozin, UV-spectrophotometric, Simultaneous estimation, Method Development and Validation, ICH Guideline.


║ Site map ║ Privacy Policy ║ Copyright ║ Terms & Conditions ║ Page Rank Tool
776,660,736 visitor(s) since 30th May, 2005.
All rights reserved. Site designed and maintained by DIVA ENTERPRISES PVT. LTD..
Note: Please use Internet Explorer (6.0 or above). Some functionalities may not work in other browsers.